D-TACC to centrosomes and to regulate astral microtubules
نویسندگان
چکیده
1 Department of Genetics, Cancer Research Campaign Cell Cycle Genetics Group, University of Cambridge, Cambridge CB2 3EH, UK 2 Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK 3 UMR 6061 Génétique et Développement, Centre National de la Recherche Scientifique, Faculté de Médecine, Université de Rennes 1, 35043 Rennes cedex, France 4 Wellcome/CRC Institute and Department of Genetics, Cambridge CB2 1QR, UK
منابع مشابه
Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules
Disruption of the function of the A-type Aurora kinase of Drosophila by mutation or RNAi leads to a reduction in the length of astral microtubules in syncytial embryos, larval neuroblasts, and cultured S2 cells. In neuroblasts, it can also lead to loss of an organized centrosome and its associated aster from one of the spindle poles, whereas the centrosome at the other pole has multiple centrio...
متن کاملAurora A activates D-TACC–Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules
Centrosomes are the dominant sites of microtubule (MT) assembly during mitosis in animal cells, but it is unclear how this is achieved. Transforming acidic coiled coil (TACC) proteins stabilize MTs during mitosis by recruiting Minispindles (Msps)/XMAP215 proteins to centrosomes. TACC proteins can be phosphorylated in vitro by Aurora A kinases, but the significance of this remains unclear. We sh...
متن کاملCaenorhabditis elegans TAC-1 and ZYG-9 Form a Complex that Is Essential for Long Astral and Spindle Microtubules
TACC (transforming acidic coiled-coil) proteins were first identified by their ability to transform cell lines [1], and links between human cancer and the overexpression of TACC proteins highlight the importance of understanding the biological function of this family of proteins. Herein, we describe the characterization of a new member of the TACC family of proteins in Caenorhabditis elegans, T...
متن کاملD-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo.
We identify Drosophila TACC (D-TACC) as a novel protein that is concentrated at centrosomes and interacts with microtubules. We show that D-TACC is essential for normal spindle function in the early embryo; if D-TACC function is perturbed by mutation or antibody injection, the microtubules emanating from centrosomes in embryos are short and chromosomes often fail to segregate properly. The C-te...
متن کاملThe TACC domain identifies a family of centrosomal proteins that can interact with microtubules.
We recently showed that the Drosophila transforming acidic coiled-coil (D-TACC) protein is located in the centrosome, interacts with microtubules, and is required for mitosis in the Drosophila embryo. There are three known human TACC proteins that share a conserved, C-terminal, coiled-coil region with D-TACC. These proteins have all been implicated in cancer, but their normal functions are unkn...
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تاریخ انتشار 2002